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Harvest and capture operations occur immediately after fermentation. Harvest vessels are the first step in separating the product from all of the other materials in the bioreactor. Impurities such as carryover cells, cell debris, and nutrient media components are removed through various filtration and centrifugation methods, depending on the product.
The product undergoes primary and sterile filtration steps between harvest and capture vessels in order to establish a baseline starting point for downstream purification operation. Often, product material is stored and frozen to await sterility, purity, and other testing prior to release for downstream processing.
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